ABSTRACT
Objective: This paper summarized the research status and progress of photodynamic therapy (PDT) and sonodynam-ic therapy (SDT), and we hope this can be a useful reference for clinics or research. Methods: In this review we expound their molecular mechanisms in detail and classify the photosensitizer and sonosensitizer, indicate their applications for the cancer treatment and summarize their new treating modes. PDT and SDT have huge potential for cancer treatment. Results: PDT and SDT have achieved a certain results, whereas there are still many problems, such as tissue oxygen content, new photosensitizer and sonosensitizer, drug dosage and mechanisms of SDT. Conclusions: PDT and SDT, which are new methods for treating cancer, have shown a good application prospect. But PDT has not been universal in clinics and SDT is still in the experiment stage.
ABSTRACT
In th is paper, an Extremely Low Frequency Multi-waveform Electromagnetic Field Generator has been developed with single chip computer, which provides pulsed, rectangular, triangular and sinusoidal magnetic field with the frequency range from 0-150 Hz and the intensity range from 0-50 mT. The application shows that the device is easy to operate and the parameters of magnetic fields are stable. It has provided successful application in the experiments on biological effects of magnetics and has obtained valuable result.
Subject(s)
Humans , Cell Differentiation , Radiation Effects , Cell Proliferation , Radiation Effects , Cells, Cultured , Electromagnetic Fields , Equipment Design , Magnetics , Osteoblasts , Radiation EffectsABSTRACT
In order to meet the needs of training high-quality medical persons, combining teaching reform theory with foundational courses teaching practice, we summarize some successful experience in many respects such as construction and reformation of foundational educational system, grasping subject construction goal, bringing up and cultivating scientific researchers, improving experimental conditions. All we have done reveal that the combination of medicine and engineering is the characteristic form of development.
ABSTRACT
The performance of extremely low-frequency electromagnetic fields (ELEF) can change the response of osteoblasts. In this study a kind of ELEF stimulator, which can radiate sinusoidal, rectangular, triangular and pulsed burst ELEF with frequency of 0-300 Hz and strength of 0-40 mT was developed. The neonatal rat calvarial osteoblasts were treated with the device. The effects of various ELEF stimulation on the osteoblast were evaluated by its proliferation and differentiation. The results demonstrated that rectangular and pulsed burst radiation (15Hz, 5mT) can positively change the proliferation of the osteoblast and inhibit its differentiation, but the sinusoidal one can significantly enhance its differentiation and decrease its proliferation.
Subject(s)
Animals , Rats , Animals, Newborn , Cell Differentiation , Radiation Effects , Cell Proliferation , Radiation Effects , Cells, Cultured , Electromagnetic Fields , Osteoblasts , Cell Biology , Radiation Effects , Rats, Sprague-Dawley , Skull , Cell BiologyABSTRACT
Objective To solve the problems of low power laser instrument with single wavelength and instable output power as well as its incapability of studying the biological effect of low intensity laser and clinical treatment. Methods The AT89S52 singlechip and PID algorithm were used. Results The desired instrument could output the wave of 532nm green laser which could be adjusted continuously from 0mW to 30mW and the wave of 650nm red laser which could be adjusted continuously from 0mW to 50mW. The error of power could be controlled within 0.1mW. Conclusion The instrument can be used to study the biological effect of low intensity laser and clinical treatment with small volume,easy operation and high stability of laser output.
ABSTRACT
This design is a multi-point thermometry system based on single bus digital thermometer DS1820.The single bus system of multi-point measure temperature is developed with single chip computer 89C52 and circuit units for physiological signal measurement.Obtainment method of higher resolution temperature data is given.The method makes measure temperature resolution reach to 0.1?C.It is characterized by simplicity of structure,high precision and real time,and is easy to transmit by internet network.So the system has widely applications value on clinic.
ABSTRACT
Low-power laser irradiation has an excellent effect when applied clinically. But existing laser apparatuses have many disadvantages such as inconvenience. So, this paper develops an intelligent semi-conductor laser therapeutic apparatus and introduces its hardware structure and software design as well as its test and clinical application.
ABSTRACT
PBL teaching model has been adopted as one of mainstream models in the west medical education.This article,with the characteristics of medical physics,combined with the advantage of PBL,discusses how PBL teaching mode is applied to medical physics.What we have done provides a reference for the development of PBL in medical physics.
ABSTRACT
This paper is todevelop a kind of VRA-I visual reinforcement audiometry used in cochlea implant for the infant.Single chip microcomputer89C2051and related hardware and software are concerned with it.Cochlea implant is successfully implanted in37cases of228deaf-mute infants tested with the device.The device can be clinically applied tothe audition test of the infant.
ABSTRACT
Objective To investigate of the biological effects of the extremely low frequency electromagnetic fields (ELFEMF),and to explore the effect of rectangular ELFEMF performance parameters on rat fetal skull osteoblast. Methods Different amplitude, frequency and duty cycle of rectangular ELFEMF were used on rat fetal skull osteoblast and the proliferation and differentiation of osteoblast were examined. Results There existed action windows of amplitude and frequency with regard to the biological effect of rectangular ELFEMF. The 15 Hz, 5 mT and 15% duty cycle could significantly promote the proliferation and decrease differentiation of the cells. Conclusion The proliferation and differentiation of osteoblast could be affected by rectangular ELFEMF characterized by its amplitude, frequency and duty cycle. This study indicated that rectangular ELFEMF of 15 Hz, 5 mT and 15% duty cycle was suitable for the proliferation and differentiation of osteoblast in vitro.
ABSTRACT
In this paper,a pulsed magnetic fields stimulation instrument is designed and realized,which provides a pulsed magnetic field with the range of maximal intensity from 0.01~2T,frequency from 0.2~100Hz and time width of pulse from 0.01~1ms.The instrument,controlled by the hand,foot or itself,can display stimulus intensity and times and output trigger signals with different waveforms to make measuring devices operate synchronistically.
ABSTRACT
In this paper, We designed and accomplished a low frequency pulsed strong magnetic fields generator, which provides a pulsed magnetic field with the intensity range from 0.1-2.5 T and the adjusted time interval of pulse. This device is easy to operate and performs reliably. It can work steady for a long time and has been successful used in the experiments of biological effects of electromagnetics.
Subject(s)
Electromagnetic Phenomena , Equipment Design , Software DesignABSTRACT
Objective To develop an apparatus to measure pulse magnetic field. Methods Single chip computer and Hall-effect integrated circuit was utilized to measure the magnetic induction. The correlative hardware and software flow were given. The measuring range of apparatus was 0-50mT. Results The circuit was simple and the performance was safe and credible. The measuring precision was high. Conclusion It can be used for some kinds of magnetic induction measurement.